Host-pathogen interactions revealed by human genome-wide surveys.


Khor, CC; Hibberd, ML; (2012) Host-pathogen interactions revealed by human genome-wide surveys. Trends in genetics, 28 (5). pp. 233-43. ISSN 0168-9525 DOI: https://doi.org/10.1016/j.tig.2012.02.001

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Abstract

: Genome-wide association studies (GWAS) have now convincingly shown that the diverse outcomes (such as the resolution of infection, clinical deterioration to severe disease, or progression from acute infection to persistent infection) that occur following microbial infection can be at least partly explained by human genetic variation. Unbiased whole-genome approaches have revealed unprecedentedly robust associations between genetic markers and susceptibility to disease, providing clear insights into our understanding of infectious disease biology by revealing the crucial host-pathogen interaction sites. Further work characterizing both the host causative variations and pathogenic microbial strains with distinct host interactions and disease outcomes is now required to provide potential new intervention strategies.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 22445588
Web of Science ID: 303634800005
URI: http://researchonline.lshtm.ac.uk/id/eprint/292306

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