Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries


Fernandez, FM; Hostetler, D; Powell, K; Kaur, H; Green, MD; Mildenhall, DC; Newton, PN; (2011) Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries. The Analyst, 136 (15). pp. 3073-3082. ISSN 0003-2654 DOI: https://doi.org/10.1039/c0an00627k

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Abstract

Throughout history, poor quality medicines have been a persistent problem, with periodical crises in the supply of antimicrobials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Regrettably, this problem seems to have grown in the last decade, especially afflicting unsuspecting patients and those seeking medicines via on-line pharmacies. Here we discuss some of the challenges related to the fight against poor quality drugs, and counterfeits in particular, with an emphasis on the analytical tools available, their relative performance, and the necessary workflows needed for distinguishing between genuine, substandard, degraded and counterfeit medicines.

Item Type: Article
Keywords: desorption electrospray-ionization, counterfeit antimalarial tablets, near-infrared spectroscopy, tandem mass-spectrometry, fake artesunate, southeast-asia, falciparum-malaria, raman-spectroscopy, ambient, conditions, real-time
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: ACT Consortium
Malaria Centre
PubMed ID: 21107455
Web of Science ID: 292972200006
URI: http://researchonline.lshtm.ac.uk/id/eprint/292

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