Comparison of microarray-predicted closest genomes to sequencing for poliovirus vaccine strain similarity and influenza A phylogeny.


Maurer-Stroh, S; Lee, CW; Patel, C; Lucero, M; Nohynek, H; Sung, WK; Murad, C; Ma, J; Hibberd, ML; Wong, CW; Simões, EA; (2015) Comparison of microarray-predicted closest genomes to sequencing for poliovirus vaccine strain similarity and influenza A phylogeny. Diagnostic microbiology and infectious disease, 84 (3). pp. 203-6. ISSN 0732-8893 DOI: https://doi.org/10.1016/j.diagmicrobio.2015.11.003

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Abstract

We evaluate sequence data from the PathChip high-density hybridization array for epidemiological interpretation of detected pathogens. For influenza A, we derive similar relative outbreak clustering in phylogenetic trees from PathChip-derived compared to classical Sanger-derived sequences. For a positive polio detection, recent infection could be excluded based on vaccine strain similarity.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 26658310
Web of Science ID: 371186500007
URI: http://researchonline.lshtm.ac.uk/id/eprint/2901245

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