Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2


Thye, T; Vannberg, FO; Wong, SH; Owusu-Dabo, E; Osei, I; Gyapong, J; Sirugo, G; Sisay-Joof, F; Enimil, A; Chinbuah, MA; Floyd, S; Warndorff, DK; Sichali, L; Malema, S; Crampin, AC; Ngwira, B; Teo, YY; Small, K; Rockett, K; Kwiatkowski, D; Fine, PE; Hill, PC; Newport, M; Lienhardt, C; Adegbola, RA; Corrah, T; Ziegler, A; African TB Genetics Consortium (inc Clark, T.G.), ; , WellcomeTrustCaseControlConsortium; Morris, AP; Meyer, CG; Horstmann, RD; Hill, AVS; (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature genetics, 42 (9). pp. 739-741. ISSN 1061-4036 DOI: 10.1038/ng.639

Full text not available from this repository.

Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Item Type: Article
Keywords: MYCOBACTERIUM-TUBERCULOSIS, WEST-AFRICA
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Population Studies (1974-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: MEIRU
Population Studies Group
TB Centre
Tropical Epidemiology Group
PubMed ID: 20694014
Web of Science ID: 281388400005
URI: http://researchonline.lshtm.ac.uk/id/eprint/2891

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
314Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item