Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Thye, Thorsten; Vannberg, Fredrik O; Wong, Sunny H; Owusu-Dabo, Ellis; Osei, Ivy; Gyapong, John; Sirugo, Giorgio; Sisay-Joof, Fatou; Enimil, Anthony; Chinbuah, Margaret A; +23 more... Floyd, Sian; Warndorff, David K; Sichali, Lifted; Malema, Simon; Crampin, Amelia C; Ngwira, Bagrey; Teo, Yik Y; Small, Kerrin; Rockett, Kirk; Kwiatkowski, Dominic; Fine, Paul E; Hill, Philip C; Newport, Melanie; Lienhardt, Christian; Adegbola, Richard A; Corrah, Tumani; Ziegler, Andreas; African TB Genetics Consortium; Wellcome Trust Case Control Consortium; Morris, Andrew P; Meyer, Christian G; Horstmann, Rolf D; Hill, Adrian VS; (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature genetics, 42 (9). pp. 739-741. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.639

Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Additional Information

Item Type	Article
Keywords	MYCOBACTERIUM-TUBERCULOSIS, WEST-AFRICA
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre	TB Centre Population Studies Group Tropical Epidemiology Group
PubMed ID	20694014
ISI	281388400005