What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?


Horby, P; Sudoyo, H; Viprakasit, V; Fox, A; Thai, PQ; Yu, H; Davila, S; Hibberd, M; Dunstan, SJ; Monteerarat, Y; Farrar, JJ; Marzuki, S; Hien, NT; (2010) What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1? Epidemiology and infection, 138 (11). pp. 1550-8. ISSN 0950-2688 DOI: 10.1017/S0950268810000518

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Abstract

The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 20236573
Web of Science ID: 282196000004
URI: http://researchonline.lshtm.ac.uk/id/eprint/2869493

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