Comparison of variance estimators for meta-analysis of instrumental variable estimates.
Schmidt, AF; Hingorani, AD; Jefferis, BJ; White, J; Groenwold, RH; Dudbridge, F; UCLEB Consortium, ; (2016) Comparison of variance estimators for meta-analysis of instrumental variable estimates. International journal of epidemiology. ISSN 0300-5771 DOI: https://doi.org/10.1093/ije/dyw123
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Abstract
Mendelian randomization studies perform instrumental variable (IV) analysis using genetic IVs. Results of individual Mendelian randomization studies can be pooled through meta-analysis. We explored how different variance estimators influence the meta-analysed IV estimate. Two versions of the delta method (IV before or after pooling), four bootstrap estimators, a jack-knife estimator and a heteroscedasticity-consistent (HC) variance estimator were compared using simulation. Two types of meta-analyses were compared, a two-stage meta-analysis pooling results, and a one-stage meta-analysis pooling datasets. Using a two-stage meta-analysis, coverage of the point estimate using bootstrapped estimators deviated from nominal levels at weak instrument settings and/or outcome probabilities ≤ 0.10. The jack-knife estimator was the least biased resampling method, the HC estimator often failed at outcome probabilities ≤ 0.50 and overall the delta method estimators were the least biased. In the presence of between-study heterogeneity, the delta method before meta-analysis performed best. Using a one-stage meta-analysis all methods performed equally well and better than two-stage meta-analysis of greater or equal size. In the presence of between-study heterogeneity, two-stage meta-analyses should preferentially use the delta method before meta-analysis. Weak instrument bias can be reduced by performing a one-stage meta-analysis.
Item Type: | Article |
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Faculty and Department: | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
Research Centre: | Centre for Statistical Methodology |
PubMed ID: | 27591262 |
Web of Science ID: | 398261100035 |
URI: | http://researchonline.lshtm.ac.uk/id/eprint/2837720 |
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[Accepted Manuscript] Comparison of variance estimators for meta-analysis of instrumental variable estimates. (deposited 12 Dec 2016 09:35)
- Comparison of variance estimators for meta-analysis of instrumental variable estimates. (deposited 13 Dec 2017 12:38) [Currently Displayed]
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