Plasma melatonin is reduced in Huntington's disease.


Kalliolia, E; Silajdžić, E; Nambron, R; Hill, NR; Doshi, A; Frost, C; Watt, H; Hindmarsh, P; Björkqvist, M; Warner, TT; (2014) Plasma melatonin is reduced in Huntington's disease. Movement disorders, 29 (12). pp. 1511-5. ISSN 0885-3185 DOI: https://doi.org/10.1002/mds.26003

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Abstract

This study was undertaken to determine whether the production of melatonin, a hormone regulating sleep in relation to the light/dark cycle, is altered in Huntington's disease. We analyzed the circadian rhythm of melatonin in a 24-hour study of cohorts of control, premanifest, and stage II/III Huntington's disease subjects. The mean and acrophase melatonin concentrations were significantly reduced in stage II/III Huntington's disease subjects compared with controls. We also observed a nonsignificant trend toward reduced mean and acrophase melatonin in premanifest Huntington's disease subjects. Onset of melatonin rise was significantly more temporally spread in both premanifest and stage II/III Huntington's disease subjects compared with controls. A nonsignificant trend also was seen for reduced pulsatile secretion of melatonin. Melatonin concentrations are reduced in Huntington's disease. Altered melatonin patterns may provide an explanation for disrupted sleep and circadian behavior in Huntington's disease, and represent a biomarker for disease state. Melatonin therapy may help the sleep disorders seen in Huntington's disease.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 25164424
Web of Science ID: 342793700008
URI: http://researchonline.lshtm.ac.uk/id/eprint/2814533

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