The source of respiratory syncytial virus infection in infants: a household cohort study in rural Kenya.


Munywoki, PK; Koech, DC; Agoti, CN; Lewa, C; Cane, PA; Medley, GF; Nokes, DJ; (2013) The source of respiratory syncytial virus infection in infants: a household cohort study in rural Kenya. The Journal of infectious diseases, 209 (11). pp. 1685-92. ISSN 0022-1899 DOI: 10.1093/infdis/jit828

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Abstract

Respiratory syncytial virus (RSV) vaccine development for direct protection of young infants faces substantial obstacles. Assessing the potential of indirect protection using different strategies, such as targeting older children or mothers, requires knowledge of the source of infection to the infants. We undertook a prospective study in rural Kenya. Households with a child born after the preceding RSV epidemic and ≥ 1 elder sibling were recruited. Nasopharyngeal swab samples were collected every 3-4 days irrespective of symptoms from all household members throughout the RSV season of 2009-2010 and tested for RSV using molecular techniques. From 451 participants in 44 households a total of 15 396 nasopharyngeal swab samples were samples were collected, representing 86% of planned sampling. RSV was detected in 37 households (84%) and 173 participants (38%) and 28 study infants (64%). The infants acquired infection from within (15 infants; 54%) or outside (9 infants; 32%) the household; in 4 households the source of infant infection was inconclusive. Older children were index case patients for 11 (73%) of the within-household infant infections, and 10 of these 11 children were attending school. We demonstrate that school-going siblings frequently introduce RSV into households, leading to infection in infants.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 24367040
Web of Science ID: 336485900003
URI: http://researchonline.lshtm.ac.uk/id/eprint/2814492

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