Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.


Aung, HL; Tun, T; Moradigaravand, D; Köser, CU; Nyunt, WW; Aung, ST; Lwin, T; Thinn, KK; Crump, JA; Parkhill, J; Peacock, SJ; Cook, GM; Hill, PC; (2016) Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar. Journal of global antimicrobial resistance, 6. pp. 113-117. ISSN 2213-7165 DOI: 10.1016/j.jgar.2016.04.008

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Abstract

Drug-resistant tuberculosis (TB) is a major health threat in Myanmar. An initial study was conducted to explore the potential utility of whole-genome sequencing (WGS) for the diagnosis and management of drug-resistant TB in Myanmar. Fourteen multidrug-resistant Mycobacterium tuberculosis isolates were sequenced. Known resistance genes for a total of nine antibiotics commonly used in the treatment of drug-susceptible and multidrug-resistant TB (MDR-TB) in Myanmar were interrogated through WGS. All 14 isolates were MDR-TB, consistent with the results of phenotypic drug susceptibility testing (DST), and the Beijing lineage predominated. Based on the results of WGS, 9 of the 14 isolates were potentially resistant to at least one of the drugs used in the standard MDR-TB regimen but for which phenotypic DST is not conducted in Myanmar. This study highlights a need for the introduction of second-line DST as part of routine TB diagnosis in Myanmar as well as new classes of TB drugs to construct effective regimens.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 27530852
URI: http://researchonline.lshtm.ac.uk/id/eprint/2782919

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