Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design


Bonsignori, M; Montefiori, DC; Wu, XL; Chen, X; Hwang, KK; Tsao, CY; Kozink, DM; Parks, RJ; Tomaras, GD; Crump, JA; Kapiga, SH; Sam, NE; Kwong, PD; Kepler, TB; Liao, HX; Mascola, JR; Haynesa, BF; (2012) Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design. Journal of virology, 86 (8). pp. 4688-4692. ISSN 0022-538X DOI: https://doi.org/10.1128/JVI.07163-11

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Abstract

Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies (bnAbs), CH01 and VRC-CH31, from two clonal lineages of memory B cells with distinct specificities (variable loop 1 and 2 [V1V2] conformational specificity and CD4-binding site specificity, respectively) that recapitulate 95% of CH0219 serum neutralization breadth. These data provide proof of concept for an HIV-1 vaccine that aims to elicit bnAbs of multiple specificities.

Item Type: Article
Keywords: immunodeficiency-virus type-1, human monoclonal-antibody, hiv-antibodies, epitope, glycoprotein, individuals, breadth, reveal, gp41, pg16, AIDS Vaccines, immunology, Antibodies, Neutralizing, genetics, immunology, metabolism, Antibody Specificity, immunology, Antigens, CD4, chemistry, metabolism, B-Lymphocytes, immunology, Binding Sites, Epitopes, chemistry, HIV Antibodies, genetics, immunology, metabolism, HIV Envelope Protein gp120, chemistry, immunology, HIV Infections, immunology, HIV-1, immunology, Humans, Immunoglobulin Variable Region, chemistry, genetics, Neutralization Tests, Phylogeny
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 22301150
Web of Science ID: 302185400062
URI: http://researchonline.lshtm.ac.uk/id/eprint/27617

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