Day care versus in-patient surgery for age-related cataract


Jagannath, VA; Fedorowicz, Z; Thaker, V; Chang, AB; (2011) Day care versus in-patient surgery for age-related cataract. Cochrane Database of Systematic Reviews (1). CD008482. ISSN 1469-493X DOI: https://doi.org/10.1002/14651858.CD008482.pub2

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Abstract

BACKGROUND: Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Supplementation with vitamin K appears to be one way of addressing the deficiency, but there is very limited agreement on the appropriate dose and frequency of use of these supplements.<br/> OBJECTIVES: To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.<br/> SEARCH STRATEGY: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Most recent search: 15 April 2010.<br/> SELECTION CRITERIA: Randomised and quasi-randomised controlled trials of all preparations of vitamin K used as a supplement compared to either no supplementation (or placebo) at any dose or route and for any duration, in children or adults diagnosed with cystic fibrosis (by sweat test or genetic testing).<br/> DATA COLLECTION AND ANALYSIS: Two authors independently screened papers, extracted trial details and assessed their risk of bias.<br/> MAIN RESULTS: Two trials (total of 32 participants) were included in the review and were assessed as having a moderate risk of bias. One was a dose-ranging parallel group trial; and the other had a cross-over design, but no separate data were reported for the first intervention period. Neither of the trials addressed any of the primary outcomes (coagulation, bone formation and quality of life). Both trials reported the restoration of serum vitamin K and undercarboxylated osteocalcin levels to the normal range after one month of daily supplementation with 1 mg of vitamin K.<br/> AUTHORS' CONCLUSIONS: Evidence from randomised controlled trials on the benefits of routine vitamin K supplementation for people with CF is currently weak and limited to two small trials of short duration. However, no harm was found and until further evidence is available, the present recommendations should be adhered to.<br/>

Item Type: Article
Keywords: Ambulatory Surgical Procedures, Cataract Extraction, Hospitalization, Feasibility Studies, Randomized Controlled Trials as Topic, Humans, avoidable blindness, rapid assessment, controlled-trials, outcomes, outpatient, india, Blood Coagulation, drug effects, Cystic Fibrosis, blood, complications, Dietary Supplements, Humans, Osteogenesis, drug effects, Quality of Life, Randomized Controlled Trials as Topic, Vitamin K, administration & dosage, Vitamin K Deficiency, complications, drug therapy, Vitamins, administration & dosage
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 21249710
Web of Science ID: 286393200034
URI: http://researchonline.lshtm.ac.uk/id/eprint/273

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