Effect of Pneumococcal Vaccination on Nasopharyngeal Carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Fijian Children


Dunne, EM; Manning, J; Russell, FM; Robins-Browne, RM; Mulholland, EK; Satzke, C; (2012) Effect of Pneumococcal Vaccination on Nasopharyngeal Carriage of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Fijian Children. Journal of clinical microbiology, 50 (3). pp. 1034-1038. ISSN 0095-1137 DOI: 10.1128/JCM.06589-11

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Abstract

The 7-valent pneumococcal conjugate vaccine (PCV7) reduces carriage of vaccine type Streptococcus pneumoniae but leads to replacement by nonvaccine serotypes and may affect carriage of other respiratory pathogens. We investigated nasopharyngeal carriage of S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in Fijian infants participating in a pneumococcal vaccine trial using quantitative PCR. Vaccination did not affect pathogen carriage rates or densities, whereas significant differences between the two major ethnic groups were observed.

Item Type: Article
Keywords: upper respiratory-tract, acute otitis-media, conjugate-vaccine, young-children, polysaccharide vaccine, healthy-children, co-colonization, infections, pathogens, bacterial, Bacterial Infections, epidemiology, microbiology, Carrier State, epidemiology, microbiology, Child, Child, Preschool, Fiji, epidemiology, Gram-Negative Bacteria, isolation & purification, Gram-Positive Bacteria, isolation & purification, Humans, Infant, Nasopharynx, microbiology, Pneumococcal Vaccines, administration & dosage, Prevalence, Vaccination, utilization
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 22170924
Web of Science ID: 300997800073
URI: http://researchonline.lshtm.ac.uk/id/eprint/27298

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