Artemisinin resistance: current status and scenarios for containment.


Dondorp, AM; Yeung, S; White, L; Nguon, C; Day, NP; Socheat, D; von Seidlein, L; (2010) Artemisinin resistance: current status and scenarios for containment. Nature reviews Microbiology, 8 (4). pp. 272-80. ISSN 1740-1526 DOI: https://doi.org/10.1038/nrmicro2331

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Abstract

Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia-Thailand border. Exposure of the parasite population to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region. A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research. Mathematical modelling can be a useful tool to evaluate possible strategies for containment.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Malaria Centre
PubMed ID: 20208550
Web of Science ID: 275701200011
URI: http://researchonline.lshtm.ac.uk/id/eprint/2702

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