Polychlorinated biphenyls (PCBs) and hydroxy-PCBs in adipose tissue of women in Southeast Spain

Fernandez, MF; Kiviranta, H; Molina-Molina, JM; Laine, O; Lopez-Espinosa, MJ; Vartiainen, T; Olea, N; (2008) Polychlorinated biphenyls (PCBs) and hydroxy-PCBs in adipose tissue of women in Southeast Spain. Chemosphere, 71 (6). pp. 1196-205. ISSN 0045-6535 DOI: https://doi.org/10.1016/j.chemosphere.2007.09.064

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Polychlorinated biphenyls (PCBs) and hydroxylated PCBs (OH-PCBs) were investigated in human adipose tissue samples collected from 20 women undergoing surgery. Mean sum of PCB and sum of OH-PCB levels were 737ng/g of lipid and 8pg/g of lipid, respectively. Among PCBs, congeners 180, 153, 138 and 170 were the most frequent and abundant, and together constituted 72% of the total amount of PCBs in adipose tissue. The PCB congener pattern and the frequencies and concentrations of non-dioxin-like and non-hydroxylated congeners observed in adipose tissue were similar in distribution and order of magnitude to the profile previously published in Spain but lower than that found in other European countries. Among OH-PCB congeners studied, 4-OH-PCB 107/118 was found at the highest concentrations followed by 3'-OH-PCB 180 and 3-OH-PCB 138. To date, no information on levels of PCB metabolites in the Spanish population is available for comparison. These three predominant OH-PCBs contributed 97% of all OH-PCBs. Twelve dioxin-like PCBs contributed around 8% of the total PCB exposure, and all were present in all study subjects. Further research is required to determine trends in human exposure to PCBs and OH-PCBs and how existing banning measures affect exposure.

Item Type: Article
Keywords: Adipose Tissue/ chemistry, Adult, Aged, Aged, 80 and over, Environmental Exposure/analysis, Female, Humans, Lipids/analysis, Middle Aged, Polychlorinated Biphenyls/ analysis/ chemistry, Spain, Adipose Tissue, chemistry, Adult, Aged, Aged, 80 and over, Environmental Exposure, analysis, Female, Humans, Lipids, analysis, Middle Aged, Polychlorinated Biphenyls, analysis, chemistry, Spain
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 18045642
Web of Science ID: 255329700023
URI: http://researchonline.lshtm.ac.uk/id/eprint/2687


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