Public Health Impact After the Introduction of PsA-TT: The First 4 Years.

Diomandé, FV; Djingarey, MH; Daugla, DM; Novak, RT; Kristiansen, PA; Collard, JM; Gamougam, K; Kandolo, D; Mbakuliyemo, N; Mayer, L; Stuart, J; Clark, T; Tevi-Benissan, C; Perea, WA; Preziosi, MP; Marc LaForce, F; Caugant, D; Messonnier, N; Walker, O; Greenwood, B; (2015) Public Health Impact After the Introduction of PsA-TT: The First 4 Years. Clinical infectious diseases, 61 Suppl 5. S467-72. ISSN 1058-4838 DOI:

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During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010-2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated. The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence. PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics. Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
PubMed ID: 26553676
Web of Science ID: 365162700014


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