LSHTM Research Online

Floud, S; Kuper, H; Reeves, GK; Beral, V; Green, J; (2016) Risk Factors for Cataracts Treated Surgically in Postmenopausal Women. Ophthalmology, 123 (8). pp. 1704-10. ISSN 0161-6420 DOI: https://doi.org/10.1016/j.ophtha.2016.04.037

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Abstract

PURPOSE: To identify risk factors for cataracts treated surgically in postmenopausal women.<br/> DESIGN: Population-based, prospective cohort study.<br/> PARTICIPANTS: A total of 1 312 051 postmenopausal women in the UK Million Women Study, aged 56 years on average (standard deviation [SD], 4.8), without previous cataract surgery, hospital admission with cataracts, or cancer at baseline, were followed for cataracts treated surgically.<br/> METHODS: Cox regression was used to calculate adjusted relative risks (RRs) for cataract surgery by lifestyle factors, treatment for diabetes, reproductive history, and use of hormonal therapies.<br/> MAIN OUTCOME MEASURES: Cataract surgery identified by linkage to central National Health Service (NHS) records for inpatient and day-patient admissions (Hospital Episode Statistics for England and Scottish Morbidity Records in Scotland).<br/> RESULTS: Overall, 89 343 women underwent cataract surgery during an average of 11 (SD, 3) years of follow-up. Women with diabetes were at greatest risk (diabetes vs. no diabetes RR, 2.90; 95% confidence interval [CI], 2.82-2.97). Other factors associated with an increased risk of cataract surgery were current smoking (current smokers of ≥15 cigarettes/day vs. never smokers RR, 1.26; 95% CI, 1.23-1.30) and obesity (body mass index [BMI] ≥30 vs. <25 kg/m(2); RR, 1.12; 95% CI, 1.10-1.14).<br/> CONCLUSIONS: Diabetes, smoking, and obesity were risk factors for cataract surgery. Alcohol use, physical activity, reproductive history, and use of hormonal therapies had little, if any, association with cataract surgery risk.<br/>

Item Type:	Article
Faculty and Department:	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID:	27282285
Web of Science ID:	380754200025
URI:	http://researchonline.lshtm.ac.uk/id/eprint/2550785

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