The Malaria-High Blood Pressure Hypothesis.


Etyang, AO; Smeeth, L; Cruickshank, JK; Scott, JA; (2016) The Malaria-High Blood Pressure Hypothesis. Circulation research, 119 (1). pp. 36-40. ISSN 0009-7330 DOI: 10.1161/CIRCRESAHA.116.308763

This is the latest version of this item. Earlier version may have full text manuscript

Full text not available from this repository. (Request a copy)

Abstract

RATIONALE: Several studies have demonstrated links between infectious diseases and cardiovascular conditions. Malaria and hypertension are widespread in many low- and middle-income countries, but the possible link between them has not been considered.<br/> OBJECTIVE: In this article, we outline the basis for a possible link between malaria and hypertension and discuss how the hypothesis could be confirmed or refuted.<br/> METHODS AND RESULTS: We reviewed published literature on factors associated with hypertension and checked whether any of these were also associated with malaria. We then considered various study designs that could be used to test the hypothesis. Malaria causes low birth weight, malnutrition, and inflammation, all of which are associated with hypertension in high-income countries. The hypothetical link between malaria and hypertension can be tested through the use of ecological, cohort, or Mendelian randomization studies, each of which poses specific challenges.<br/> CONCLUSIONS: Confirmation of the existence of a causative link with malaria would be a paradigm shift in efforts to prevent and control hypertension and would stimulate wider research on the links between infectious and noncommunicable disease.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: EHR Research Group
PubMed ID: 27151400
Web of Science ID: 378496500009
URI: http://researchonline.lshtm.ac.uk/id/eprint/2548708

Available Versions of this Item

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
37Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item