Post-Treatment Effect of Isoniazid Preventive Therapy on Tuberculosis Incidence in Hiv-Infected Individuals on Antiretroviral Therapy.


Sumner, T; Houben, RM; Rangaka, MX; Maartens, G; Boulle, A; Wilkinson, RJ; White, RG; (2016) Post-Treatment Effect of Isoniazid Preventive Therapy on Tuberculosis Incidence in Hiv-Infected Individuals on Antiretroviral Therapy. AIDS (London, England), 30 (8). pp. 1279-86. ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0000000000001078

[img] Text - Accepted Version
License:

Download (1MB)

Abstract

BACKGROUND: In HIV-uninfected individuals, isoniazid preventive therapy (IPT) has been associated with long-term protection against tuberculosis (TB). For HIV-infected/antiretroviral therapy (ART)-naive individuals, high TB rates have been observed following completion of IPT, consistent with a lack of 'cure' of infection. Recent trial data of IPT among HIV-infected individuals on ART in Khayelitsha, South Africa, have suggested that the effect of IPT persisted following completion of IPT.<br/> METHODS: Using mathematical modelling, we explored if this increased duration of protection may be due to an increased curative ability of IPT when given in combination with ART. The model was used to estimate the annual risk of infection and proportion of individuals whose latent infection was 'cured' by IPT, defined such that they must be reinfected to be at risk of disease.<br/> RESULTS: The estimated annual risk of infection was 4.0% (2.6-5.8) and the estimated proportion of individuals whose latent Mycobacterium tuberculosis infection was cured following IPT was 35.4% (2.4-76.4), higher than that previously estimated for HIV-infected/ART-naive individuals. Our results suggest that IPT can cure latent M. tuberculosis infection in approximately one-third of HIV-infected individuals on ART and therefore provide protection beyond the period of treatment.<br/> CONCLUSION: Among HIV-infected individuals on ART in low incidence settings, 12 months of IPT may provide additional long-term benefit. Among HIV-infected individuals on ART in high incidence settings, the durability of this protection will be limited because of continued risk of reinfection, and continuous preventive therapy together with improved infection control efforts will be required to provide long-term protection against TB.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: TB Centre
PubMed ID: 26950316
Web of Science ID: 375781200013
URI: http://researchonline.lshtm.ac.uk/id/eprint/2535265

Statistics


Download activity - last 12 months
Downloads since deposit
15Downloads
96Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item