B cell sub-types following acute malaria and associations with clinical immunity.


Sullivan, RT; Ssewanyana, I; Wamala, S; Nankya, F; Jagannathan, P; Tappero, JW; Mayanja-Kizza, H; Muhindo, MK; Arinaitwe, E; Kamya, M; Dorsey, G; Feeney, ME; Riley, EM; Drakeley, CJ; Greenhouse, B; Sullivan, R; (2016) B cell sub-types following acute malaria and associations with clinical immunity. Malar J, 15 (1). p. 139. ISSN 1475-2875 DOI: 10.1186/s12936-016-1190-0

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Abstract

Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria. To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria-lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia. Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria. These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Malaria Centre
Vaccine Centre
PubMed ID: 26939776
Web of Science ID: 371464200001
URI: http://researchonline.lshtm.ac.uk/id/eprint/2535017

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