Cost-effectiveness analysis: discount the placebo at your peril.


Hawkins, N; Scott, DA; (2010) Cost-effectiveness analysis: discount the placebo at your peril. Medical decision making, 30. pp. 536-43. ISSN 0272-989X DOI: https://doi.org/10.1177/0272989X10362106

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Abstract

INTRODUCTION: The authors consider alternative mechanisms that might explain placebo responses and their implications for cost-effectiveness modeling. Three alternative placebo mechanisms are examined: a ''regression to the mean'' effect arising from natural variation and the preferential selection of patients with acutely severe disease into clinical trials, a patient expectancy effect specific to the clinical trial setting (Hawthorne effect), and a patient expectancy effect generalizable to routine clinical practice (true placebo effect).

Item Type: Article
Keywords: Clinical Trials as Topic, Cost-Benefit Analysis, Epilepsy, Epilepsy: drug therapy, Humans, Models, Economic, Outcome Assessment (Health Care), Patient Care, Patient Care: economics, Patient Care: methods, Placebo Effect, Quality-Adjusted Life Years, Clinical Trials as Topic, Cost-Benefit Analysis, Epilepsy, drug therapy, Humans, Models, Economic, Outcome Assessment (Health Care), Patient Care, economics, methods, Placebo Effect, Quality-Adjusted Life Years
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 20228282
Web of Science ID: 283174800006
URI: http://researchonline.lshtm.ac.uk/id/eprint/2534883

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