Glycopeptide vs. non-glycopeptide antibiotics for prophylaxis of surgical site infections: a systematic review.


Chambers, D; Worthy, G; Myers, L; Weatherly, H; Elliott, R; Hawkins, N; Sculpher, M; Eastwood, A; (2010) Glycopeptide vs. non-glycopeptide antibiotics for prophylaxis of surgical site infections: a systematic review. Surgical infections, 11. pp. 455-462. ISSN 1096-2964 DOI: https://doi.org/10.1089/sur.2009.055

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Abstract

Patients receive prophylactic antibiotics against surgical site infections (SSIs) before or during many procedures. Glycopeptide antibiotics are effective against most strains of methicillin-resistant Staphylococcus aureus (MRSA), but their wider use risks increasing resistance. Our objective was to review the evidence for clinical effectiveness that might help to determine whether there is a threshold of MRSA prevalence at which switching from non-glycopeptide to glycopeptide antibiotic prophylaxis might be justified.

Item Type: Article
Keywords: Anti-Bacterial Agents, therapeutic use, Antibiotic Prophylaxis, methods, Bacterial Infections, prevention & control, Glycopeptides, therapeutic use, Humans, Preoperative Care, methods, Randomized Controlled Trials as Topic, Surgical Wound Infection, prevention & control, Treatment Outcome
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 20815758
Web of Science ID: 283027900008
URI: http://researchonline.lshtm.ac.uk/id/eprint/2534515

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