The rise, fall, and possible resurrection of renal denervation.


Gulati, R; Raphael, CE; Negoita, M; Pocock, SJ; Gersh, BJ; (2016) The rise, fall, and possible resurrection of renal denervation. Nature reviews Cardiology, 13 (4). pp. 238-44. ISSN 1759-5002 DOI: https://doi.org/10.1038/nrcardio.2016.1

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Abstract

: Renal denervation has a chequered history. Dramatic reductions in blood pressure after denervation of the renal arteries were observed in early trials, but later trials in which denervation was tested against a sham procedure produced neutral results. Although a sound pathophysiological basis exists for interruption of the renal sympathetic nervous system as a treatment for hypertension, trial data to date are insufficient to support renal denervation as an established clinical therapy. In this Perspectives article, we summarize the currently available trial data, device development, and trials in progress, and provide recommendations for future trial design.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 26843285
Web of Science ID: 372344200009
URI: http://researchonline.lshtm.ac.uk/id/eprint/2534219

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