Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages.


Andersson, P; Harris, SR; Smith, HM; Hadfield, J; O'Neill, C; Cutcliffe, LT; Douglas, FP; Asche, LV; Mathews, JD; Hutton, SI; Sarovich, DS; Tong, SY; Clarke, IN; Thomson, NR; Giffard, PM; (2016) Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages. Nat Commun, 7. p. 10688. ISSN 2041-1723 DOI: https://doi.org/10.1038/ncomms10688

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Abstract

Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases. Here we report the whole-genome sequences of ocular C. trachomatis isolates obtained from young children with clinical signs of trachoma in a trachoma endemic region of northern Australia. The isolates form two lineages that fall outside the classical trachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree. The Australian trachoma isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that encode immunodominant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocular isolates. This suggests that ocular tropism and association with trachoma are functionally associated with some sequence variants of ompA and pmpEFGH.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 26912299
Web of Science ID: 371028700006
URI: http://researchonline.lshtm.ac.uk/id/eprint/2534130

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