Intracellular replication of the well-armed pathogen Burkholderia pseudomallei.


Willcocks, SJ; Denman, CC; Atkins, HS; Wren, BW; (2016) Intracellular replication of the well-armed pathogen Burkholderia pseudomallei. Current opinion in microbiology, 29. pp. 94-103. ISSN 1369-5274 DOI: 10.1016/j.mib.2015.11.007

[img]
Preview
Text - Published Version
License:

Download (645Kb) | Preview

Abstract

The Burkholderia genus contains a group of soil-dwelling Gram-negative organisms that are prevalent in warm and humid climates. Two species in particular are able to cause disease in animals, B. mallei primarily infects Equus spp. and B. pseudomallei (BPS), that is able to cause potentially life-threatening disease in humans. BPS is naturally resistant to many antibiotics and there is no vaccine available. Although not a specialised human pathogen, BPS possesses a large genome and many virulence traits that allow it to adapt and survive very successfully in the human host. Key to this survival is the ability of BPS to replicate intracellularly. In this review we highlight recent advances in our understanding of the intracellular survival of BPS, including how it overcomes host immune defenses and other challenges to establish its niche and then spread the infection. Knowledge of these mechanisms increases our capacity for therapeutic interventions against a well-armed foe.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 26803404
Web of Science ID: 371651500015
URI: http://researchonline.lshtm.ac.uk/id/eprint/2534107

Statistics


Download activity - last 12 months
Downloads since deposit
21Downloads
52Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item