Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro.


Patin, EC; Willcocks, S; Orr, S; Ward, TH; Lang, R; Schaible, UE; (2016) Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro. Innate immunity, 22 (3). pp. 181-5. ISSN 1753-4259 DOI: https://doi.org/10.1177/1753425916636671

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Abstract

: The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 26939595
Web of Science ID: 373228700005
URI: http://researchonline.lshtm.ac.uk/id/eprint/2533979

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