Hearing loss in children treated for multidrug-resistant tuberculosis.
Seddon, James A;
Thee, Stephanie;
Jacobs, Kayleen;
Ebrahim, Adam;
Hesseling, Anneke C;
Schaaf, H Simon;
(2012)
Hearing loss in children treated for multidrug-resistant tuberculosis.
The Journal of infection, 66 (4).
pp. 320-329.
ISSN 0163-4453
DOI: https://doi.org/10.1016/j.jinf.2012.09.002
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OBJECTIVE: The aminoglycosides and polypeptides are vital drugs for the management of multidrug-resistant (MDR) tuberculosis (TB). Both classes of drug cause hearing loss. We aimed to determine the extent of hearing loss in children treated for MDR-TB. METHODS: In this retrospective study, children (<15 years) admitted to Brooklyn Chest Hospital, Cape Town, South Africa, from January 2009 until December 2010, were included if treated for MDR-TB with injectable drugs. Hearing was assessed and classified using audiometry and otoacoustic emissions. RESULTS: Ninety-four children were included (median age: 43 months). Of 93 tested, 28 (30%) were HIV-infected. Twenty-three (24%) children had hearing loss. Culture-confirmed, as opposed to presumed, diagnosis of TB was a risk factor for hearing loss (OR: 4.12; 95% CI: 1.13-15.0; p = 0.02). Seven of 11 (64%) children classified as having hearing loss using audiometry had progression of hearing loss after finishing the injectable drug. CONCLUSIONS: Hearing loss is common in children treated for MDR-TB. Alternative drugs are required for the treatment of paediatric MDR-TB.