Metabolites of Aliphatic Alcohols Detected in Alcoholic Beverages Inhibit Phagocytosis.


Árnyas, EM; Pál, L; Baranyi, G; Bujdosó, O; Rácz, G; Ádány, R; McKee, M; Szűcs, S; (2015) Metabolites of Aliphatic Alcohols Detected in Alcoholic Beverages Inhibit Phagocytosis. Alcohol and alcoholism (Oxford, Oxfordshire), 51 (4). pp. 388-94. ISSN 0735-0414 DOI: https://doi.org/10.1093/alcalc/agv132

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Abstract

AIMS: The aim of our study was to measure granulocyte and monocyte phagocytosis following treatment of cells with some metabolites of aliphatic alcohols alone and in combination with acetaldehyde.<br/> METHODS: The cells were separated from human peripheral blood prior to determination of phagocytosis of opsonized zymosan particles by granulocytes and monocytes treated individually with metabolites of aliphatic alcohols including formaldehyde, 1-propanal, acetone, 1-butanal, and 2-butanone and in combination with acetaldehyde.<br/> RESULTS: The findings revealed that metabolites of aliphatic alcohols inhibited phagocytosis by granulocytes and monocytes in a concentration-dependent manner and when combined with acetaldehyde, they caused a further decrease in phagocytic activity.<br/> CONCLUSION: Due to their additive effects, it is possible that, in combination with acetaldehyde, metabolites of aliphatic alcohols may inhibit phagocytosis at physiologically realistic concentrations in episodic heavy drinkers, thereby contributing to their increased susceptibility to infectious diseases.<br/>

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Health Services Research and Policy
PubMed ID: 26715358
Web of Science ID: 379699000002
URI: http://researchonline.lshtm.ac.uk/id/eprint/2478721

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