Antiprotozoal Activity of Drimane and Coloratane Sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum In Vitro


Wube, AA; Bucar, F; Gibbons, S; Asres, K; Rattray, L; Croft, SL; (2010) Antiprotozoal Activity of Drimane and Coloratane Sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum In Vitro. Phytotherapy research, 24 (10). pp. 1468-1472. ISSN 0951-418X DOI: https://doi.org/10.1002/ptr.3126

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Abstract

The extracts and 12 sesquiterpenes obtained from the East African medicinal plant Warburgia ugandensis Sprague (Canellaceae) were assessed for their antiplasmodial activity against the chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum and antitrypanosomal activity against Trypanosoma brucei rhodesiense. The dichloromethane extract displayed strong antiplasmodial and antitrypanosomal activities with IC50 values of 8.10 and 1.10 mu g/mL against K1 strain of the malaria parasite and STIB900 strain of T. b. rhodesiense, respectively. Among the compounds evaluated for inhibition of trypomastigotes, both drimane and coloratane sesquiterpenes possessing aldehyde groups at positions 8 and 9 were found to show most antitrypanosomal activity with IC50 values in the range 0.56-6.4 mu M. The antiplasmodial assays also revealed that the six coloratane and six drimane sesquiterpenes isolated from this extract exhibited significant antitrypanosomal activity with IC50 values ranged from 0.45 to > 114 mu M. Among the compounds tested against the malarial parasite P. falciparum 11 alpha-hydroxymuzigadiolide (3) was most active with an IC50 value of 6.40 mu M. Copyright (c) 2010 John Wiley & Sons, Ltd.

Item Type: Article
Keywords: Warburgia ugandensis, coloratane sesquiterpenes, drimane, sesquiterpenes, antiplasmodial, antitrypanosomal, ANTIPLASMODIAL ACTIVITIES, WARBURGIA-UGANDENSIS, AFRICAN TRYPANOSOMES, SENSITIVITY, LACTONES, INVITRO, MALARIA, PLANTS
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 20878696
Web of Science ID: 282657600009
URI: http://researchonline.lshtm.ac.uk/id/eprint/2473

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