When to Stop a Clinical Trial Early for Benefit: Lessons Learned and Future Approaches

Zannad, F; Stough, WG; McMurray, JJV; Remme, WJ; Pitt, B; Borer, JS; Geller, NL; Pocock, SJ; (2012) When to Stop a Clinical Trial Early for Benefit: Lessons Learned and Future Approaches. Circulation Heart failure, 5 (2). pp. 294-302. ISSN 1941-3289 DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.111.965707

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Item Type: Article
Keywords: clinical trial, clinical trials data monitoring committees, data, interpretation, statistical stopping rules for benefit, chronic heart-failure, cardiac-resynchronization therapy, data, monitoring experience, randomized-trial, ventricular-arrhythmia, cardiovascular events, myocardial-infarction, high-risk, mortality, morbidity, Clinical Trials as Topic, Decision Making, Heart Failure, therapy, Humans, Time Factors, Withholding Treatment, standards
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Statistical Methodology
PubMed ID: 22438522
Web of Science ID: 302120800031
URI: http://researchonline.lshtm.ac.uk/id/eprint/24646


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