Survival of HIV-infected patients after starting tuberculosis treatment: a prospective cohort study.


Maruza, M; Albuquerque, MF; Braga, MC; Barbosa, MT; Byington, R; Coimbra, I; Moura, LV; Batista, JD; Diniz, GT; Miranda-Filho, DB; Lacerda, HR; Rodrigues, LC; Ximenes, RA; (2012) Survival of HIV-infected patients after starting tuberculosis treatment: a prospective cohort study. The international journal of tuberculosis and lung disease, 16 (5). pp. 618-24. ISSN 1027-3719 DOI: https://doi.org/10.5588/ijtld.11.0110

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Abstract

OBJECTIVES: To estimate the probability of survival and to evaluate risk factors for death in a cohort of persons living with human immunodeficiency virus (PLHIV) who had started tuberculosis (TB) treatment. METHODS: A prospective cohort study was conducted between June 2007 and December 2009 with HIV-infected patients who had started anti-tuberculosis treatment in the State of Pernambuco, Brazil. Survival data were analysed using the Kaplan-Meier estimator, the log-rank test and the Cox model. Hazard ratios and their respective 95%CIs were estimated. RESULTS: Of a cohort of 2310 HIV-positive individuals, 333 patients who had commenced treatment for TB were analysed. The mortality rate was 5.25 per 10?000 person-years (95%CI 4.15-6.63). The probability of survival at 30 months was 74%. Risk factors for death in the study population were being female, age ?30 years, having anaemia, not using highly active antiretroviral therapy (HAART) during treatment for TB and disseminated TB. Protective factors for death were a CD4 lymphocyte count >200 cells/mm(3) and treatment for TB having started in an out-patient clinic. CONCLUSIONS: The use of HAART can prevent deaths among HIV-TB patients, corroborating the efficacy of starting HAART early in individuals with TB.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 22410415
Web of Science ID: 303700600012
URI: http://researchonline.lshtm.ac.uk/id/eprint/24642

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