Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


Houlston, RS; Webb, E; Broderick, P; Pittman, AM; Di Bernardo, MC; Lubbe, S; Chandler, I; Vijayakrishnan, J; Sullivan, K; Penegar, S; Colorectal Cancer Association Study Consortium, ; Carvajal-Carmona, L; Howarth, K; Jaeger, E; Spain, SL; Walther, A; Barclay, E; Martin, L; Gorman, M; Domingo, E; Teixeira, AS; CoRGI Consortium, ; Kerr, D; Cazier, JB; Niittymäki, I; Tuupanen, S; Karhu, A; Aaltonen, LA; Tomlinson, IP; Farrington, SM; Tenesa, A; Prendergast, JG; Barnetson, RA; Cetnarskyj, R; Porteous, ME; Pharoah, PD; Koessler, T; Hampe, J; Buch, S; Schafmayer, C; Tepel, J; Schreiber, S; Völzke, H; Chang-Claude, J; Hoffmeister, M; Brenner, H; Zanke, BW; Montpetit, A; Hudson, TJ; Gallinger, S; International Colorectal Cancer Genetic Association Consortium, ; Campbell, H; Dunlop, MG; (2008) Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nature genetics, 40 (12). pp. 1426-35. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.262

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Abstract

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci with similar effect sizes, we conducted a meta-analysis of two GWA studies, comprising 13,315 individuals genotyped for 38,710 common tagging SNPs. We undertook replication testing in up to eight independent case-control series comprising 27,418 subjects. We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)). These findings underscore the value of large sample series for discovery and follow-up of genetic variants contributing to the etiology of CRC.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 19011631
Web of Science ID: 261215900019
URI: http://researchonline.lshtm.ac.uk/id/eprint/2447

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