Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis.


Matakidou, A; El Galta, R; Rudd, MF; Webb, EL; Bridle, H; Eisen, T; Houlston, RS; (2007) Further observations on the relationship between the FGFR4 Gly388Arg polymorphism and lung cancer prognosis. British journal of cancer, 96 (12). pp. 1904-7. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6603816

[img]
Preview
Text - Published Version
License:

Download (88kB) | Preview

Abstract

The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. To determine whether Gly388Arg is a marker for lung cancer prognosis, we genotyped 619 lung cancer patients with incident disease and examined the relationship between genotype and overall survival. While we employed a comprehensive set of statistical tests, including those sensitive to the detection of differences in early survival, our data provide little evidence to support the tenet that the FGFR4 Gly388Arg polymorphism is a clinically useful marker for lung cancer prognosis.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 17519899
Web of Science ID: 247218100019
URI: http://researchonline.lshtm.ac.uk/id/eprint/2431

Statistics


Download activity - last 12 months
Downloads since deposit
236Downloads
266Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item