Sample selection and validity of exposure-disease association estimates in cohort studies.


Pizzi, C; De Stavola, B; Merletti, F; Bellocco, R; Dos Santos Silva, I; Pearce, N; Richiardi, L; (2010) Sample selection and validity of exposure-disease association estimates in cohort studies. Journal of epidemiology and community health. ISSN 0143-005X DOI: 10.1136/jech.2009.107185

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Abstract

Background Participants in cohort studies are frequently selected from restricted source populations. It has been recognised that such restriction may affect the study validity. Objectives To assess the bias that may arise when analyses involve data from cohorts based on restricted source populations, an area little studied in quantitative terms. Methods Monte Carlo simulations were used, based on a setting where the exposure and one risk factor for the outcome, which are not associated in the general population, influence selection into the cohort. All the parameters involved in the simulations (ie, prevalence and effects of exposure and risk factor on both the selection and outcome process, selection prevalence, baseline outcome incidence rate, and sample size) were allowed to vary to reflect real life settings. Results The simulations show that when the exposure and risk factor are strongly associated with selection (ORs of 4 or 0.25) and the unmeasured risk factor is associated with a disease HR of 4, the bias in the estimated log HR for the exposure-disease association is ±0.15. When these associations decrease to values more commonly seen in epidemiological studies (eg, ORs and HRs of 2 or 0.5), the bias in the log HR drops to just ±0.02. Conclusions Using a restricted source population for a cohort study will, under a range of sensible scenarios, produce only relatively weak bias in estimates of the exposure-disease associations.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 20881022
Web of Science ID: 289079700007
URI: http://researchonline.lshtm.ac.uk/id/eprint/2408

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