New strategies for the elimination of polio from India.


Grassly, NC; Fraser, C; Wenger, J; Deshpande, JM; Sutter, RW; Heymann, DL; Aylward, RB; (2006) New strategies for the elimination of polio from India. Science (New York, NY), 314 (5802). pp. 1150-3. ISSN 0036-8075 DOI: 10.1126/science.1130388

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Abstract

The feasibility of global polio eradication is being questioned as a result of continued transmission in a few localities that act as sources for outbreaks elsewhere. Perhaps the greatest challenge is in India, where transmission has persisted in Uttar Pradesh and Bihar despite high coverage with multiple doses of vaccine. We estimate key parameters governing the seasonal epidemics in these areas and show that high population density and poor sanitation cause persistence by not only facilitating transmission of poliovirus but also severely compromising the efficacy of the trivalent vaccine. We analyze strategies to counteract this and show that switching to monovalent vaccine may finally interrupt virus transmission.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 17110580
Web of Science ID: 242045800046
URI: http://researchonline.lshtm.ac.uk/id/eprint/2382

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