New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.


Sillitoe, I; Cuff, AL; Dessailly, BH; Dawson, NL; Furnham, N; Lee, D; Lees, JG; Lewis, TE; Studer, RA; Rentzsch, R; Yeats, C; Thornton, JM; Orengo, CA; (2012) New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic acids research, 41 (Database issue). D490-8. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gks1211

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Abstract

: CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups. When focusing on structural genomics (SG) structures, we observe that the number of new folds for CATH v3.5 is slightly less than for previous releases, and this observation suggests that we may now know the majority of folds that are easily accessible to structure determination. We have improved the accuracy of our functional family (FunFams) sub-classification method and the CATH sequence domain search facility has been extended to provide FunFam annotations for each domain. The CATH website has been redesigned. We have improved the display of functional data and of conserved sequence features associated with FunFams within each CATH superfamily.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 23203873
Web of Science ID: 312893300070
URI: http://researchonline.lshtm.ac.uk/id/eprint/2374036

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