Current challenges in genome annotation through structural biology and bioinformatics.


Furnham, N; de Beer, TA; Thornton, JM; (2012) Current challenges in genome annotation through structural biology and bioinformatics. Current opinion in structural biology, 22 (5). pp. 594-601. ISSN 0959-440X DOI: https://doi.org/10.1016/j.sbi.2012.07.005

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Abstract

: With the huge volume in genomic sequences being generated from high-throughout sequencing projects the requirement for providing accurate and detailed annotations of gene products has never been greater. It is proving to be a huge challenge for computational biologists to use as much information as possible from experimental data to provide annotations for genome data of unknown function. A central component to this process is to use experimentally determined structures, which provide a means to detect homology that is not discernable from just the sequence and permit the consequences of genomic variation to be realized at the molecular level. In particular, structures also form the basis of many bioinformatics methods for improving the detailed functional annotations of enzymes in combination with similarities in sequence and chemistry.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 22884875
Web of Science ID: 310766200010
URI: http://researchonline.lshtm.ac.uk/id/eprint/2374035

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