Noncoding RNA in Mycobacteria


Arnvig, KB; Cortes, T; Young, DB; (2014) Noncoding RNA in Mycobacteria. Microbiology spectrum, 2 (2). ISSN 2165-0497 DOI: https://doi.org/10.1128/microbiolspec.MGM2-0029-2013

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Abstract

Efforts to understand the molecular basis of mycobacterial gene regulation are dominated by a protein-centric view. However, there is a growing appreciation that noncoding RNA, i.e., RNA that is not translated, plays a role in a wide variety of molecular mechanisms. Noncoding RNA comprises rRNA, tRNA, 4.5S RNA, RnpB, and transfer-messenger RNA, as well as a vast population of regulatory RNA, often dubbed "the dark matter of gene regulation." The regulatory RNA species comprise 5' and 3' untranslated regions and a rapidly expanding category of transcripts with the ability to base-pair with mRNAs or to interact with proteins. Regulatory RNA plays a central role in the bacterium's response to changes in the environment, and in this article we review emerging information on the presence and abundance of different types of noncoding RNA in mycobacteria.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 26105815
URI: http://researchonline.lshtm.ac.uk/id/eprint/2374006

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