Physiological phenotyping of dementias using emotional sounds.


Fletcher, PD; Nicholas, JM; Shakespeare, TJ; Downey, LE; Golden, HL; Agustus, JL; Clark, CN; Mummery, CJ; Schott, JM; Crutch, SJ; Warren, JD; (2015) Physiological phenotyping of dementias using emotional sounds. Alzheimer's & dementia (Amsterdam, Netherlands), 1 (2). pp. 170-178. ISSN 2352-8729 DOI: https://doi.org/10.1016/j.dadm.2015.02.003

[img]
Preview
Text - Published Version
License:

Download (785kB) | Preview

Abstract

Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds. Pupil responses and affective valence ratings for nonverbal sounds of varying emotional salience were assessed in patients with behavioral variant frontotemporal dementia (bvFTD) (n = 14), semantic dementia (SD) (n = 10), progressive nonfluent aphasia (PNFA) (n = 12), and AD (n = 10) versus healthy age-matched individuals (n = 26). Referenced to healthy individuals, overall autonomic reactivity to sound was normal in Alzheimer's disease (AD) but reduced in other syndromes. Patients with bvFTD, SD, and AD showed altered coupling between pupillary and affective behavioral responses to emotionally salient sounds. Emotional sounds are a useful model system for analyzing how dementias affect the processing of salient environmental signals, with implications for defining pathophysiological mechanisms and novel biomarker development.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 26634223
URI: http://researchonline.lshtm.ac.uk/id/eprint/2373960

Statistics


Download activity - last 12 months
Downloads since deposit
96Downloads
128Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item