Quality of Antimalarials at the Epicenter of Antimalarial Drug Resistance: Results from an Overt and Mystery Client Survey in Cambodia.


Yeung, S; Lawford, HL; Tabernero, P; Nguon, C; van Wyk, A; Malik, N; DeSousa, M; Rada, O; Boravann, M; Dwivedi, P; Hostetler, DM; Swamidoss, I; Green, MD; Fernandez, FM; Kaur, H; (2015) Quality of Antimalarials at the Epicenter of Antimalarial Drug Resistance: Results from an Overt and Mystery Client Survey in Cambodia. The American journal of tropical medicine and hygiene, 92 (6 Suppl). pp. 39-50. ISSN 0002-9637 DOI: 10.4269/ajtmh.14-0391

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Abstract

: Widespread availability of monotherapies and falsified antimalarials is thought to have contributed to the historical development of multidrug-resistant malaria in Cambodia. This study aimed to document the quality of artemisinin-containing antimalarials (ACAs) and to compare two methods of collecting antimalarials from drug outlets: through open surveyors and mystery clients (MCs). Few oral artemisinin-based monotherapies and no suspected falsified medicines were found. All 291 samples contained the stated active pharmaceutical ingredient (API) of which 69% were considered good quality by chemical analysis. Overall, medicine quality did not differ by collection method, although open surveyors were less likely to obtain oral artemisinin-based monotherapies than MCs. The results are an encouraging indication of the positive impact of the country's efforts to tackle falsified antimalarials and artemisinin-based monotherapies. However, poor-quality medicines remain an ongoing challenge that demands sustained political will and investment of human and financial resources.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Antimicrobial Resistance Centre (AMR)
PubMed ID: 25897063
Web of Science ID: 355785600007
URI: http://researchonline.lshtm.ac.uk/id/eprint/2338306

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