The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records


Piscitelli, P; Barba, M; Crespi, M; Di Maio, M; Santoriello, A; D'Aiuto, M; Fucito, A; Losco, A; Pentimalli, F; Maranta, P; Chitano, G; Argentiero, A; Neglia, C; Distante, A; Di Tanna, GL; Brandi, ML; Mazza, A; Marino, IR; Giordano, A; Human Health Foundation Study Group, in memory of Prof. Giovan G, ; (2012) The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records. Journal of experimental & clinical cancer research, 31. p. 96. ISSN 0392-9078 DOI: https://doi.org/10.1186/1756-9966-31-96

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Abstract

: Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to capture incident breast cancer cases in Italy.<br/> : We analyzed NHDRs for mastectomies and quadrantectomies performed between 2001 and 2008. The average annual percentage change (AAPC) and related 95% Confidence Interval (CI) in the actual number of mastectomies and quadrantectomies performed during the study period were computed for the full sample and for subgroups defined by age, surgical procedure, macro-area and singular Region. Re-admissions of the same patients were separately presented.<br/> : The overall number of mastectomies decreased, with an AAPC of -2.1% (-2.3 -1.8). This result was largely driven by the values observed for women in the 45 to 64 and 65 to 74 age subgroups (-3.0%, -3.4 -3.6 and -3.3%, -3.8 -2.8, respectively). We observed no significant reduction in mastectomies for women in the remaining age groups. Quadrantectomies showed an overall +4.7 AAPC (95%CI:4.5-4.9), with no substantial differences by age. Analyses by geographical area showed a remarkable decrease in mastectomies, with inter-regional discrepancies possibly depending upon variability in mammography screening coverage and adherence. Quadrantectomies significantly increased, with Southern Regions presenting the highest average rates. Data on repeat admissions within a year revealed a total number of 46,610 major breast surgeries between 2001 and 2008, with an overall +3.2% AAPC (95%CI:2.8-3.6).<br/> : In Italy, NHDRs might represent a valuable supplemental data source to integrate Cancer Registries in cancer surveillance.<br/>

Item Type: Article
Keywords: Adult, Aged, *Breast Neoplasms/epidemiology/pathology/surgery, Female, *Hospital Records, Humans, Italy/epidemiology, Mammography, *Mastectomy, Middle Aged, *Patient Discharge, Survival Rate, Adult, Aged, Breast Neoplasms, epidemiology, pathology, surgery, Female, Hospital Records, Humans, Italy, epidemiology, Mammography, Mastectomy, Middle Aged, Patient Discharge, Survival Rate
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 23168067
Web of Science ID: 313892500001
URI: http://researchonline.lshtm.ac.uk/id/eprint/2338131

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