Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial


Mongardini, C; Di Tanna, GL; Pilloni, A; (2012) Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial. Lasers in medical science, 29 (1). pp. 1-8. ISSN 0268-8921 DOI: https://doi.org/10.1007/s10103-012-1225-x

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Abstract

: Eradication or suppression of pathogens is a major goal in periodontal therapy. Due to the increase in antibiotic resistance, the need of new disinfection therapies is raising. Photodynamic therapy (PDT) has demonstrated anti-infective potential. No data are available on the use of light-emitting diode (LED) lights as the light source in PDT. The aim of this study was to investigate the microbiological and clinical adjunctive outcome of a new photodynamic LED device, compared to scaling and root planing in periodontitis patients in maintenance [supportive periodontal therapy (SPT)]. In this masked, split-mouth design study, 30 treated chronic periodontitis subjects (mean age, 46.2 years; 13 males) in SPT were included. Two residual interdental sites with probing pocket depth (PPD) ≥ 5 mm in two opposite quadrants, with positive bleeding on probing (BOP) and comparable periodontal breakdown, were selected. PPD, BOP and subgingival microbiological samples for real-time PCR analysis (Carpegen® PerioDiagnostics, Carpegen GmbH, Münster, Germany) were recorded at baseline and 1 week after treatment. Scaling and root planing was performed under local anesthesia. Randomly one of the sites was selected to receive adjunctive photodynamic therapy by inserting a photosensitizer (toluidine blue O solution) and exposing it to a LED light in the red spectrum (Fotosan, CMS Dental, Copenhagen, Denmark), according to the manufacturer's instructions. After 1 week, 73 % of the control sites and 27 % of the test sites were still BOP+. These differences compared to baseline values and in-between groups were statistically significantly different (p < 0.001). Mean PPD decreased from 5.47 mm (±0.68) to 4.73 mm (±0.74, p < 0.001) in control sites and from 5.63 mm (±0.85) to 4.43 mm (±1.25, p < 0.001, test vs control p = 0.01) in the test group. Microbiologically, higher reductions of relative proportions of red complex bacteria were observed in test sites (68.1 vs. 4.1 %; p = 0.01). This study showed that adjunctive photodynamic treatment by LED light may enhance short-term clinical and microbiological outcome in periodontitis subjects in SPT.<br/>

Item Type: Article
Keywords: Adult, Bacterial Load, Dental Plaque/microbiology/therapy, Disinfection/*methods, Female, Humans, Male, Middle Aged, Periodontal Pocket/therapy, Periodontitis/*microbiology/*therapy, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Phototherapy/*methods, Single-Blind Method, Adult, Bacterial Load, Dental Plaque, microbiology, therapy, Disinfection, methods, Female, Humans, Male, Middle Aged, Periodontal Pocket, therapy, Periodontitis, microbiology, therapy, Photochemotherapy, methods, Photosensitizing Agents, therapeutic use, Phototherapy, methods, Single-Blind Method
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 23139071
Web of Science ID: 329834200001
URI: http://researchonline.lshtm.ac.uk/id/eprint/2338124

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