Impact of intensified case-finding strategies on childhood TB case registration in Nepal.

Joshi, B; Chinnakali, P; Shrestha, A; Das, M; Kumar, AM; Pant, R; Lama, R; Sarraf, RR; Dumre, SP; Harries, AD; (2015) Impact of intensified case-finding strategies on childhood TB case registration in Nepal. Public health action, 5 (2). pp. 93-8. ISSN 2220-8372 DOI:

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Seven intervention districts with intensified childhood tuberculosis (TB) case-finding strategies implemented by a non-governmental organisation and seven control districts under the National Tuberculosis Programme, Nepal. To assess the differences in childhood TB case registrations and case registration rates per 100 000 population between two time periods (Year 1 = March 2012-March 2013 and Year 2 = March 2013-March 2014) in intervention and control districts. Retrospective record review using routinely collected data. Childhood TB cases increased from 271 to 360 between Years 1 and 2 in the intervention districts (case registration rate from 18.2 to 24.2/100 000) and from 97 to 113 in the control districts (13.4 to 15.6/100 000): the increases were significantly higher in the intervention districts compared with the control districts. The increases were also significantly higher in children aged 0-4 years and in those with smear-negative pulmonary TB and extra-pulmonary TB. Of the various case-finding strategies, household contact screening, private-public mix services and mobile health chest camps produced the highest yield of TB. A package of intensified case-finding strategies in children was associated with an increase in childhood TB case registrations in Nepal. Additional diagnostic approaches to increase case registrations also need to be considered. Abstract available from the publisher. Abstract available from the publisher.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
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PubMed ID: 26400376
Web of Science ID: 375448900003


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