Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions.


Brown, AE; Gifford, RJ; Clewley, JP; Kucherer, C; Masquelier, B; Porter, K; Balotta, C; Back, NK; Jorgensen, LB; de Mendoza, C; Bhaskaran, K; Gill, ON; Johnson, AM; Pillay, D; Concerted Action on Seroconversion to AIDS and Death in Europe (, ; (2009) Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions. The Journal of infectious diseases, 199 (3). pp. 427-31. ISSN 0022-1899 DOI: https://doi.org/10.1086/596049

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Abstract

Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 19133810
Web of Science ID: 262326600019
URI: http://researchonline.lshtm.ac.uk/id/eprint/2309

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