Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron


Hider, RC; Silva, AMN; Podinovskaia, M; Ma, YM; (2010) Monitoring the efficiency of iron chelation therapy: the potential of nontransferrin-bound iron. Annals of the New York Academy of Sciences, 1202. pp. 94-99. ISSN 0077-8923 DOI: https://doi.org/10.1111/j.1749-6632.2010.05573.x

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Abstract

The major ligands of nontransferrin-bound iron (NTBI) are suggested to be citrate and albumin. The proportion of iron binding to albumin is influenced by the degree of oxidation and glycation of the protein. LC-ICP-MS is demonstrated to be a useful technique for the speciation of NTBI, with unprocessed scrum being subjected to analysis. Ferritin iron, citrate iron, and ferrioxamine can be quantified using this technique. This review describes the use of a new fluorescent probe for NTBI quantification.

Item Type: Article
Keywords: nontransferrin-bound iron, fluorescent reagent, HUMAN SERUM-ALBUMIN, BETA-THALASSEMIA, CHEMISTRY, OVERLOAD, PLASMA, Chelation Therapy, Citric Acid, chemistry, metabolism, Fluorescent Dyes, chemistry, metabolism, Humans, Iron, chemistry, metabolism, Iron Chelating Agents, therapeutic use, Molecular Structure, Transferrin, metabolism, Treatment Outcome
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 20712779
Web of Science ID: 283099600016
URI: http://researchonline.lshtm.ac.uk/id/eprint/2292

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