Serological markers for Leishmania donovani infection in Nepal: agreement between direct agglutination test and rK39 ELISA


Khanal, B; Rijal, S; Ostyn, B; Picado, A; Gidwani, K; Menten, J; Jacquet, D; Lejon, V; Chappuis, F; Boelaert, M; (2010) Serological markers for Leishmania donovani infection in Nepal: agreement between direct agglutination test and rK39 ELISA. Tropical medicine & international health, 15 (11). pp. 1390-1394. ISSN 1360-2276 DOI: https://doi.org/10.1111/j.1365-3156.2010.02631.x

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Abstract

Visceral leishmaniasis (VL) is an important vector-borne disease caused by Leishmania donovani in the Indian subcontinent. The actual incidence and role of asymptomatic infections in the region are not well known. We used the direct agglutination test (DAT) and the rK39 ELISA as L. donovani infection markers in 10 VL endemic villages in Nepal. DAT titre distribution showed two subgroups in the population (infected and non-infected individuals), while rK39 did not. The agreement between both tests was moderate (kappa = 0.53; 95% CI 0.49-0.57). More research is needed to develop validated markers for Leishmania infection.

Item Type: Article
Keywords: visceral leishmaniasis, kala-azar, Leishmania donovani, infection, markers, LINKED-IMMUNOSORBENT-ASSAY, INDIAN VISCERAL LEISHMANIASIS, RECOMBINANT, K-39 ANTIGEN, KALA-AZAR, DIAGNOSIS, ANTIBODY, EPIDEMIOLOGY, DISEASE
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Leishmaniasis Group
Web of Science ID: 283169000017
URI: http://researchonline.lshtm.ac.uk/id/eprint/2290

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