Brief Report: The Effect of Antiretroviral Therapy and CD4 Count on Markers of Infectiousness in HIV-Associated Tuberculosis.


van Halsema, CL; Fielding, KL; Chihota, VN; George, EC; Lewis, JJ; Churchyard, GJ; Grant, AD; (2015) Brief Report: The Effect of Antiretroviral Therapy and CD4 Count on Markers of Infectiousness in HIV-Associated Tuberculosis. Journal of acquired immune deficiency syndromes (1999), 70 (1). pp. 104-108. ISSN 1525-4135 DOI: https://doi.org/10.1097/QAI.0000000000000684

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Abstract

Clinical features of tuberculosis influence infectiousness. This cross-sectional study examined the effect of combination antiretroviral therapy (cART) and CD4 on sputum smear-positivity (SS+) and pulmonary cavitation among 1589 (1185/1589 HIV-positive) miners in South Africa. Proportions SS+ varied nonlinearly by CD4 with greatest proportions SS+ (55.3%) in the lowest stratum (<100 cells/μL). Adjusted prevalence ratio for SS+; on vs. off cART was 0.90 (95% confidence interval: 0.73 to 1.11). Proportions with cavitation varied linearly with CD4, with no independent cART effect (adjusted prevalence ratio 1.17; 95% confidence interval: 0.80 to 1.71). cART did not independently affect SS+ or cavitation but may increase infectiousness through CD4 recovery.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Evaluation
HIV Research Group
TB Centre
Tropical Epidemiology Group
PubMed ID: 26322671
Web of Science ID: 360347900014
URI: http://researchonline.lshtm.ac.uk/id/eprint/2287482

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