Biosignatures of Exposure/Transmission and Immunity.


King, CL; Davies, DH; Felgner, P; Baum, E; Jain, A; Randall, A; Tetteh, K; Drakeley, CJ; Greenhouse, B; (2015) Biosignatures of Exposure/Transmission and Immunity. The American journal of tropical medicine and hygiene, 93 (3 Suppl). pp. 16-27. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.15-0037

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Abstract

: A blood test that captures cumulative exposure over time and assesses levels of naturally acquired immunity (NAI) would provide a critical tool to monitor the impact of interventions to reduce malaria transmission and broaden our understanding of how NAI develops around the world as a function of age and exposure. This article describes a collaborative effort in multiple International Centers of Excellence in Malaria Research (ICEMRs) to develop such tests using malaria-specific antibody responses as biosignatures of transmission and immunity. The focus is on the use of Plasmodium falciparum and Plasmodium vivax protein microarrays to identify a panel of the most informative antibody responses in diverse malaria-endemic settings representing an unparalleled spectrum of malaria transmission and malaria species mixes before and after interventions to reduce malaria transmission.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: EHR Research Group
PubMed ID: 26259938
Web of Science ID: 361255000003
URI: http://researchonline.lshtm.ac.uk/id/eprint/2287477

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