Is asymptomatic malaria really asymptomatic? Hematological, vascular and inflammatory effects of asymptomatic malaria parasitaemia.


de Mast, Q; Brouwers, J; Syafruddin, D; Bousema, T; Baidjoe, AY; de Groot, PG; van der Ven, AJ; Fijnheer, R; (2015) Is asymptomatic malaria really asymptomatic? Hematological, vascular and inflammatory effects of asymptomatic malaria parasitaemia. The Journal of infection, 71 (5). pp. 587-96. ISSN 0163-4453 DOI: https://doi.org/10.1016/j.jinf.2015.08.005

Full text not available from this repository.

Abstract

: Asymptomatic malaria infections are highly prevalent in malaria endemic regions and most of these infections remain undiagnosed and untreated. Whereas conventional malaria symptoms are by definition absent, little is known on the more subtle health consequences of these infections. The aim of our study was to analyze the hematologic, vascular and inflammatory effects of patent and subpatent asymptomatic malaria parasitemia in children and adults on the Indonesian island Sumba. Both children and adults with parasitemia had increased high-sensitive C-reactive protein levels compared to aparasitemic individuals. In addition, children, but not adults with parasitemia also had lower platelet counts and Hb levels and higher levels of von Willebrand factor and platelet factor-4, markers of endothelial and platelet activation, respectively. These findings suggest that asymptomatic malaria infections have subtle health consequences, especially in children, and should be regarded as potentially harmful.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 26304688
Web of Science ID: 368479700011
URI: http://researchonline.lshtm.ac.uk/id/eprint/2287457

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
266Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item