The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study.

Anders, KL; Thompson, CN; Thuy, NT; Nguyet, NM; Tu, LT; Dung, TT; Phat, VV; Van, NT; Hieu, NT; Tham, NT; Ha, PT; Lien, LB; Chau, NV; Baker, S; Simmons, CP; (2015) The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study. International journal of infectious diseases. ISSN 1201-9712 DOI:

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Previous studies indicate a high burden of diarrhoeal disease in Vietnamese children, however longitudinal community-based data on burden and aetiology are limited. We present findings from a large, prospective cohort study of diarrhoeal disease in infants in southern Vietnam. Infants were enrolled at birth in urban Ho Chi Minh City and a semi-rural district in southern Vietnam, and followed for 12 months (n=6,706). Diarrhoeal illness episodes were identified through clinic-based passive surveillance, hospital admissions and self-reports. The minimum incidence of diarrhoeal illness in the first year of life was 271/1,000 infant-years of observation for the whole cohort. Rotavirus was the most commonly detected pathogen (50% of positive samples), followed by norovirus (24%), Campylobacter (20%), Salmonella (18%) and Shigella (16%). Repeat infections were identified in 9% of infants infected with rotavirus, norovirus, Shigella or Campylobacter, and 13% of those with Salmonella infections. We prospectively quantified the minimum incidence of diarrhoeal disease in infants in both urban and semi-rural settings in southern Vietnam. A large proportion of laboratory-diagnosed disease was caused by rotavirus and norovirus. These data highlight the unmet need for a rotavirus vaccine in Vietnam and provide evidence of the previously unrecognized burden of norovirus in infants.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 25813553
Web of Science ID: 358004000002


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