Positive selection analysis of overlapping reading frames is invalid.


Monit, C; Goldstein, RA; Towers, G; Hue, S; (2015) Positive selection analysis of overlapping reading frames is invalid. AIDS research and human retroviruses. ISSN 0889-2229 DOI: https://doi.org/10.1089/AID.2015.0150

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Abstract

In a recent ARHR publication by Roy et al., the authors report the identification of 30 codon sites under positive selection in the first exon of the HIV--1 tat gene. Unfortunately, the authors have not considered the presence of overlapping coding sequences in HIV--1, invalidating most of their positive selection analysis.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 26123213
Web of Science ID: 361395500001
URI: http://researchonline.lshtm.ac.uk/id/eprint/2266898

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